Coatings for the Pharmaceutical Industrie
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EASTMAN™ CAP
(also known as Cellacefate) enteric coating material is a pH-sensitive cellulose derivative designed for coating pharmaceutical tablets or granules. It may also be used as a matrix material in solid dose forms.
It meets USP / NF and EP-specifications and is available in powder and pellet form. |
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EASTMAN™ CA is commonly used in osmotic (controlled-release) drug delivery and taste-masking. It can be used as film coating, as matrix former in direct compression of tablets or as polymer matrix in solid dispersions. EASTMAN™ CA is made under cGMP and meets the requirements of the National Formulary (NF) and European Pharmacopoeia (EP). It is the subject of U.S. Drug Master File 9323.
Two pharmaceutical grades are available:
EASTMAN™ CA 398-10 NF/EP, cellulose acetate Ph.Eur.
EASTMAN™ CA 320S NF/EP, cellulose acetate Ph.Eur. |
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EASTMAN™ CAB - When cellulose is esterified with both acetyl and butyryl radicals to form the mixed ester, cellulose acetate butyrate, many of the desirable properties of both esters are obtained. EASTMAN™ CAB 171-15 NF cellaburate, can be used as coating material as the semi-permeable membrane for osmotic drug delivery. It is also used for taste-masking and sustained release tableting. EASTMAN™ CAB 171-15 NF is made under cGMP and meets the requirements of the National Formulary (NF) and is the subject of U.S. Drug Master File 15490.
It is available in powder form. |
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MANTROCEL® HPMC is a semi-synthetic, water-soluble derivative of the naturally occurring polymer cellulose. It is widely used as a coating agent, thickener, binder, emulsifier and suspending agent in pharmaceutical and cosmetic formulations, as well as in food products. It excels because of its ease of handling, good safety profile and the availability of a broad variety of different grades that cover a wide range of applications.
MANTROCEL® is available in two types of substitutions: E and K. The E type corresponds to Hypromellose 2910 and the K type to Hypromellose 2208, according to the EP and USP. |
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Shellac is the purified form of the natural resin lac. It is excreted by Kerria lacca and collected in its raw form from different trees in India, Burma, Thailand and China. After collection, it is grinded, mechanically separated from wood pieces and other contaminants and washed with water. Seed lac, as it is called in this stage of purification, is a complex mixture of shellolic acid, aleuritic acid and other aliphatic and alicyclic acids, wax and colouring components.
We offer ethanolic and aqueous shellac resins and glazes for film and seal coating for the pharmaceutical and food industry from Mantrose. Other grades for application in personal care are also available:
CERTIFIED® Pharmaceutical Glaze - Industry standard for over 50 years for high gloss finishing.
CRYSTALAC® - Shellac glazes provide a consistent high quality gloss from pan to package, without overnight tray drying.
CRYSTALAC® Zein - A vegetable-based protein, which can be used as a general film coat or enteric coating for pills and other encapsulated foods and drugs. GMO-free, clear, odourless, tasteless and water-insoluble.
CERTISEAL® coatings increase film build rates and produce a superior finish.
CERTISEAL® 100 A. Shellac undergoes aging because it contains free carboxylic and hydroxyl-groups that allow selfesterification. Aging leads to a loss in solubility, an increase in the glass transition temperature and a decrease in the acid value. In the case of pharmaceutical coatings, this can result in an undesired change of the drug release profile. Certiseal 100 A is an ammoniacal aqueous shellac solution that is far less prone to aging than shellac from ethanolic solutions. After drying, it forms a shellac ammonium salt that is more stable than free acid. Moreover, as an aqueous solution, it is easier to handle as a solvent-based shellac coating solution. |
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