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Colartix® , hydrolysed collagen type II matrix delivering multiple joint health benefits

Extracted from natural sources, Colartix® is a unique hydrolysed cartilage matrix that contains hydrolysed collagen Type II in the form of bioactive peptides and other matrix components. Its unique composition contains the same matrix ingredients, found in human cartilage as well. Its effects on users: Colartix® provides multiple joint health benefits, including reduction of joint inflammation.



Colartix effects on joint health, as demonstrated in scientific studies

Colartix® has been shown to be an effective joint health ingredient in a recent set of in vivo studies. Its efficacy was demonstrated in the context of injury-related osteoarthritis, as well as a combined mouse model of post-traumatic and obesity-induced osteoarthritis.

In a model for post-traumatic osteoarthritis, joint injury induces the loss of cartilage (matrix and cells) and a strong local inflammation of the knee joint. Supplementation with Colartix at a low dose clearly demonstrated the following:

  • Protection of the cartilage from degeneration (normalization of cartilage area, blue bar) and promotion of lubrication through the stimulation of proteoglycan synthesis in chondrocytes (increase in % of active cells, blue bar).
    • Protects and lubricates


    Cartilage area and number of SafraninO-positive staining cells in knee joint histologies of mice with and without post-traumatic osteoarthritis after a 3 week supplementation with control or Colartix; OA-osteoarthritis.
  • Promotion of anti-inflammatory action in the knee joint (reducing local expression of inflammation markers in the synovial membrane, blue bar).
    • Reduces Inflammation

    TNF mRNA expression in the synovium of mice with and without post-traumatic osteoarthritis after a 3 week supplementation period with control or Colartix; OA-osteoarthritis.


    In a model for obesity-associated osteoarthritis combined with injury, the loss of cartilage (matrix and cells) and local inflammation of the knee joint were induced in an even shorter time. Colartix supplementation at a low dose resulted in a preventative effect helping to:
  • Protect the cartilage from degeneration (normalization of cartilage area, blue bar) and promote lubrication by stimulating proteoglycan synthesis in chondrocytes (increase in % of active cells, blue bar) in animals rendered obese by means of a high-fat diet.
    • Protects & lubricates in obesity-associated OA


    Cartilage area and number of SafraninO-positive staining cells in knee joint histologies of HFD-fed mice with and without post-traumatic osteoarthritis after a 3 week supplementation period with control or Colartix; OA-osteoarthritis.
  • Efficient protection of the knee joint from local, synovial inflammation (reducing local expression of inflammation markers in the synovial membrane, see the absence of brown staining in comparison to control animals, as indicated by the arrows) in animals rendered obese by means of a high-fat diet.
    Brown staining represents inflammation. In the obese OA – control image, the staining is apparent, while in the obese OA – Colartix® image, there is no staining.
    • Reduces inflammation in obesity-associated OA


    TNF immunohistochemistry in knee joints of HFD-fed mice with and without post-traumatic osteoarthritis after a 3 week supplementation period with control or Colartix; OA-osteoarthritis; M-meniscus, F-femur, T-tibia.


    Highly bioavailable

    Studies have shown Colartix® has a high absorption rate, indicated by high levels of hydroxyproline after one hour of ingestion.

    Efficient absorption


    Serum hydroxyproline in mice 1h after ingestion of a Colartix bolus, after a supplementation period of 3 weeks and 12 weeks respectively.



    Using Colartix to uniquely position your joint health supplement in the market

    If you are a nutraceutical manufacturer seeking to serve consumers who are in pursuit of an active, healthy lifestyle, Colartix® offers you the perfect solution.

  • An all-natural, bioactive and safe ingredient
    •  Colartix® is a unique hydrolysed cartilage extracted from natural sources, it contains hydrolysed collagen type II in the form of bio-available peptides and glycosaminoglycans (GAGs) of which chondroitin sulfate and hyaluronic acid. Colartix® is absorbed by the body and works on location. Colartix® is a single ingredient that can simultaneously deliver triple joint health benefits.

  • Low daily dosage for maximum convenience
    •  Consumers today want joint health supplements that offer convenience. Colartix® supports joint health at a low daily dosage (1-3 g/day), feasible for tablets and capsules, allowing consumers to easily ingest the product.

  • Designed for use in tablets and capsules, while being cold water-soluble
    •  Having a good flowability and consistent powder specification, Colartix® is fully adapted for tableting processes and can be encapsulated. While, at the same time, it has excellent cold water solubility, allowing incorporation in functional food and beverage solutions, such as liquid shots. It is also possible to formulate in nutritional confectioneries.

  • FDA-notified GRAS and clean label
    •  Colartix® is a natural, clean label, non-drug nutraceutical ingredient.


    Further Information about Colartix® :

    Leaflet Colartix®




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